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August 10, 2026Journal of AOAC InternationalOpen Access

Development and Validation of an ICP-MS Method using Ammonium Fluoride to Replace Hydrofluoric Acid for Analysis of Cosmetic Ingredients

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Authors

MTMai TamuraEMEri MatsumotoNSNaoki Sakakibara

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Overview

Randomized trial analyzes elemental impurities in cosmetic ingredients, suggesting enhanced safety measures.

Key Points

  • This study aims to develop and validate a new method for analyzing elemental impurities in cosmetics using ammonium fluoride.
  • Total dissolution of eight cosmetic ingredients was achieved through microwave digestion.
  • Inductively coupled plasma mass spectrometry was used to quantify 14 elemental impurities.
  • The method was validated for limits of detection, quantification, accuracy, and precision.
  • Inorganic ingredients showed higher concentrations of elemental impurities than organic ones.
  • Selenium, cadmium, and mercury were not detected in any samples.
  • The method confirmed its suitability for reliable determination of total elemental impurities.

Cite This Study

Tamura et al. (2026) studied this question.

synapsesocial.com/papers/6a797d3a9c20a9bbd31847a3https://doi.org/10.1093/jaoacint/qsag067
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