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The review aims to evaluate the health impacts of sucralose, particularly in metabolic and microbiome contexts.

Sucralose and Human Health: Metabolic, Microbiome, Neuroendocrine, Toxicological, and Environmental Perspectives

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The review aims to evaluate the health impacts of sucralose, particularly in metabolic and microbiome contexts.
Consolidated evidence on chemistry, pharmacokinetics, and health effects of sucralose from animal and human studies.
Analyzed impacts on gut microbiota, specifically reductions in beneficial bacteria like Bifidobacteria.
Assessed environmental persistence and proposed future research priorities in high-risk populations.
Sucralose is associated with dose-dependent gut dysbiosis, notably reduced Bifidobacteria and Lactobacilli.
Altered incretin and T1R2/T1R3 signaling contributes to hepatic insulin resistance and glucose intolerance, especially in vulnerable individuals.
While regulatory safety results are mainly supported by toxicological data, methodological flaws and interspecies variations were recognized.

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Review analyzes sucralose impacts on metabolism and the microbiome, suggesting further research needs.

Qadir et al. (2026) studied this question.

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