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In a tryptophan auxotroph of Escherichia coli, the replacement of tryptophan by azatryptophan or by tryptazan allows the formation of active alkaline phosphatase. Substitution of tryptophan by these analogues has little effect on the structure and function of the enzyme. The main effect is seen in the ultraviolet absorbance and fluorescent spectra of the purified proteins.
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Sondra Schlesinger (1968) studied this question.
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