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March 16, 1999Proceedings of the National Academy of SciencesOpen Access

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways

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Authors

PCPatrick CostelloThe Francis Crick InstituteAWAlice E. WaltersNational Institute for Medical ResearchPMP. Joseph MeeRoslin Institute

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Costello et al. (1999) studied this question.

synapsesocial.com/papers/6a797fa806bbdce3610207d7https://doi.org/10.1073/pnas.96.6.3035
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction1998 · 403 citations
  2. 2Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway1995 · 1,454 citations
  3. 3Activation of nuclear factor-kappaB via T cell receptor requires a Raf kinase and Ca2+ influx. Functional synergy between Raf and calcineurin1996 · 78 citations
  4. 4Signal transduction through NF-κB1998 · 1,098 citations
  5. 5Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton.1995 · 537 citations