Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene.

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Population

Synovial cell clones (SCCs) established from three asymptomatic HTLV-I carriers with synovial overgrowth

Design

Preclinical

Authors

Discussion

May link HTLV-I tax to synovial hyperplasia; leaves open its role in human inflammatory joint disease.

Population

Synovial cell clones (SCCs) established from three asymptomatic HTLV-I carriers with synovial overgrowth

Intervention

Presence of HTLV-I proviral DNA expressing the tax gene, or transfection with tax expression plasmid

Outcome

Synovial cell proliferation and cytokine expressionsurrogate

The HTLV-I tax gene appears to play a critical role in driving synovial overgrowth, suggesting a mechanism for chronic inflammatory synovitis.

Nakajima et al. (1993) studied this question.

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