Why the study?
Does measurement of epoxide hydrolase activity in amniocytes predict the risk of fetal hydantoin syndrome in pregnancies exposed to anticonvulsant drugs?
Population
19 pregnancies monitored by amniocentesis exposed to anticonvulsant drugs, plus a randomly selected sample…
Comparison
Measurement of epoxide hydrolase activity in… vs Fetuses with enzyme activity >30% of standard
Design
Cohort
Follow-up
after birth
Authors
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May stratify risk in anticonvulsant-exposed pregnancies; hypothesis-generating and requires prospective validation before adoption.
Does measurement of epoxide hydrolase activity in amniocytes predict the risk of fetal hydantoin syndrome in pregnancies exposed to anticonvulsant drugs?
Measurement of epoxide hydrolase activity in amniocytes may identify fetuses at increased risk for congenital malformations induced by anticonvulsant drugs.
Buehler et al. (1990) studied this question.
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