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Phase-separated nanoaggregation of a highly loaded 9,10-bis[4'-(4''-aminostyryl)styryl]anthracene dye in organically modified silica (ORMOSIL) nanoparticles boosts intracellular two-photon fluorescence signal by virtue of enhanced two-photon absorption and emission, high chromophore number density in the nano-space, and noninvasive cellular uptake.
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Kim et al. (2007) studied this question.
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