Anti-inflammatory gene therapy in the donor improves graft function after lung transplantation

▴ Tagawa T, Dharmarajan S, Hayama M, et al . Endobronchial gene transfer of soluble type I interleukin-1 receptor ameliorates lung graft ischemia-reperfusion injury. Ann Thorac Surg2004;78:1932–9 [OpenUrl][1][PubMed][2] Ischaemia-reperfusion injury remains an important cause of primary graft failure and early mortality after lung transplantation. Interleukin (IL)-1, an early response and potent pro-inflammatory cytokine, has been implicated in the pathophysiology. In this paper the role of transfection of donor lungs with an adenoviral vector for soluble type … [1]: {openurl}?query=rft.jtitle%253DThe%2BAnnals%2Bof%2BThoracic%2BSurgery%26rft.stitle%253DAnn.%2BThorac.%2BSurg.%26rft.issn%253D0003-4975%26rft.aulast%253DTagawa%26rft.auinit1%253DT.%26rft.volume%253D78%26rft.issue%253D6%26rft.spage%253D1932%26rft.epage%253D1939%26rft.atitle%253DEndobronchial%2BGene%2BTransfer%2Bof%2BSoluble%2BType%2BI%2BInterleukin-1%2BReceptor%2BAmeliorates%2BLung%2BGraft%2BIschemia-Reperfusion%2BInjury%26rft_id%253Dinfo%253Apmid%252F15561003%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=15561003&link_type=MED&atom=%2Fthoraxjnl%2F60%2F4%2F319.atom