March 1, 1998Human Gene Therapy
Adenovirus-Mediated Interleukin-10 Gene Transfer Inhibits Post-Transplant Fibrous Airway Obliteration in an Animal Model of Bronchiolitis Obliterans
Why the study?
Does IL-10 administration prevent fibrous airway obliteration in a rat model of bronchiolitis obliterans?
Population
Rat heterotopic tracheal transplant model of bronchiolitis obliterans
Comparison
Interleukin-10 administered either in… vs Untreated controls and replication-defective…
Design
Preclinical
Follow-up
3 weeks
Authors
Discussion
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Member takes
Implication
May support IL-10 in rat transplant models; leaves open translation to clinical bronchiolitis obliterans.
Structured PICO
Does IL-10 administration prevent fibrous airway obliteration in a rat model of bronchiolitis obliterans?
P
Population
Rat heterotopic tracheal transplant model of bronchiolitis obliterans
I
Intervention
Interleukin-10 (IL-10) administered either in recombinant form by osmotic minipump or by adenoviral-mediated IL-10 gene transfer (Ad5E1mIL-10), initiated 5 days after transplantation
C
Comparator
Untreated controls and replication-defective adenovirus (Ad5d170-3) control vector
O
Outcome
Development of fibrous airway obliteration assessed histologically based on a scoring system at 3 weeks after transplantationsurrogate
IL-10 administration, either recombinant or via gene transfer, prevents fibrous airway obliteration in a rat model of bronchiolitis obliterans when initiated 5 days post-transplant.
Cite This Study
Boehler et al. (1998) studied this question.