Why the study?
Does intracoronary administration of adv-vIL-10 prolong allograft survival in a rat heart transplant model?
Population
Rat heart transplant models (syngeneic ACI to ACI and highly histoincompatible ACI to LEW)
Comparison
Intracoronary administration of adenoviral… vs No treatment, adenoviral beta-galactosidase…
Design
Preclinical
Authors
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Does not support clinical use of adv-vIL-10; leaves open its role in human heart transplantation pending further studies.
Does intracoronary administration of adv-vIL-10 prolong allograft survival in a rat heart transplant model?
Intracoronary gene transfer of viral IL-10 prolongs heart allograft survival and acts synergistically with cyclosporine A in a rat model of acute rejection.
Zuo et al. (1998) studied this question.
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