Key result
Ex vivo lentiviral gene transfer of RANTES 9-68 significantly prolonged cardiac allograft survival to a median of 20 days compared to 15 days in controls (P=0.0007).
Why the study?
Does ex vivo lentiviral gene transfer of RANTES 9-68 prolong heart graft survival in a rat allograft model?
Population
Fisher donor/Lewis recipient rat strain combinations undergoing cardiac allograft transplantation
Comparison
Ex vivo gene transfer into heart allograft by… vs Control (received subtherapeutic cyclosporine A)
Design
Preclinical
Follow-up
Until graft rejection (median 20 days)
Authors
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Hypothesis-generating for chemokine antagonism in transplantation; leaves open translation from this rat model.
Does ex vivo lentiviral gene transfer of RANTES 9-68 prolong heart graft survival in a rat allograft model?
Absolute Event Rate: 20% vs 15%
p-value: p=0.0007
Ex vivo lentiviral gene transfer of the chemokine antagonist RANTES 9-68 significantly prolongs cardiac allograft survival in a rat model, suggesting a potential strategy for organ preservation.
Vassalli et al. (2006) studied Cardiac allograft rejection. Ex vivo gene transfer of lentiviral vector encoding RANTES 9-68 vs. Control was evaluated on Graft survival (median days) (p=0.0007). Ex vivo lentiviral gene transfer of RANTES 9-68 significantly prolonged cardiac allograft survival to a median of 20 days compared to 15 days in controls (P=0.0007).
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