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May 1, 2000The Journal of ImmunologyOpen Access

Tolerance to Cardiac Allografts Via Local and Systemic Mechanisms After Adenovirus-Mediated CTLA4Ig Expression

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Why the study?

Does adenovirus-mediated CTLA4Ig gene transfer prevent cardiac allorejection and prolong allograft survival in a rat model?

Population

Rat model of cardiac transplantation

Comparison

Adenovirus-mediated CTLA4Ig gene transfer into… vs Controls and systemic CTLA4Ig protein injection

Design

Preclinical

Follow-up

Up to 1 year

Authors

CGCécile GuillotPMPatrick MathieuHCHélène Coathalem

Discussion

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Overview

Should not change clinical practice; leaves open translation of CTLA4Ig gene therapy to human cardiac allografts.

Structured PICO

Does adenovirus-mediated CTLA4Ig gene transfer prevent cardiac allorejection and prolong allograft survival in a rat model?

P
Population
Rat model of cardiac transplantation
I
Intervention
Adenovirus-mediated CTLA4Ig gene transfer into the myocardium
C
Comparator
Controls (untreated/standard) and systemic CTLA4Ig protein injection
O
Outcome
Cardiac allograft survivalsurrogate

Adenovirus-mediated CTLA4Ig gene transfer into the myocardium induces long-lasting local and systemic immunomodulation, leading to indefinite cardiac allograft survival and donor-specific tolerance in a rat model.

Cite This Study

Guillot et al. (2000) studied this question.

synapsesocial.com/papers/6a98f34dd2b4da1de4bd463ehttps://doi.org/10.4049/jimmunol.164.10.5258
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TRANSPLANTATION TOLERANCE INDUCED BY CTLA4-Ig11994 · 298 citations
  2. 2Prolonged survival of heart allografts transduced with AAV‐CTLA4Ig2003 · 9 citations
  3. 3Adeno-Associated Virus–Mediated CTLA4Ig Gene Transfer Protects MHC-Mismatched Renal Allografts from Chronic Rejection2006 · 29 citations
  4. 4Anti-CD4 Monoclonal Antibody-Induced Tolerance to MHC-Incompatible Cardiac Allografts Maintained by CD4+ Suppressor T Cells That Are Not Dependent upon IL-41998 · 69 citations
  5. 5Gene Transfer of Programmed Death Ligand-1.Ig Prolongs Cardiac Allograft Survival2006 · 44 citations