Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1998The Journal of ImmunologyOpen Access

Anti-CD4 Monoclonal Antibody-Induced Tolerance to MHC-Incompatible Cardiac Allografts Maintained by CD4+ Suppressor T Cells That Are Not Dependent upon IL-4

View Full Paper
Ask AI
Bookmark
Share

Population

Naive DA rats receiving fully allogeneic PVG strain heterotopic cardiac allografts

Design

Preclinical

Follow-up

>100 days

Authors

BHBruce M. HallLFLisa FavaJCJuchuan Chen

Discussion

Loading...

Member takes

Overview

Supports CD4+ suppressor T-cell tolerance in rodent cardiac allografts; leaves open translation to clinical transplantation.

Structured PICO

P
Population
Naive DA rats receiving fully allogeneic PVG strain heterotopic cardiac allografts
I
Intervention
MRC Ox38, a nondepleting anti-CD4 monoclonal antibody
O
Outcome
Graft survival and cytokine mRNA expression (IL-2, IFN-gamma, TNF-beta, IL-4, IL-6)surrogate

Anti-CD4 mAb-induced tolerance to cardiac allografts is maintained by CD4+ suppressor T cells independent of IL-4 or preferential Th2 cytokine induction.

Cite This Study

Hall et al. (1998) studied this question.

synapsesocial.com/papers/6a73a7c69e855e455c27a007https://doi.org/10.4049/jimmunol.161.10.5147
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1COMBINED THERAPY WITH INTERLEUKIN-4 AND INTERLEUKIN-10 INHIBITS AUTOIMMUNE DIABETES RECURRENCE IN SYNGENEIC ISLET-TRANSPLANTED NONOBESE DIABETIC MICE ANALYSIS OF CYTOKINE MRNA EXPRESSION IN THE GRAFT1995 · 76 citations
  2. 2Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.1994 · 601 citations
  3. 3In vivo effects of anti-IL-4 monoclonal antibody on neonatal induction of tolerance and on an associated autoimmune syndrome.1990 · 88 citations
  4. 4LYMPHOCYTE SUBPOPULATIONS AND MEMORY OF MHC ANTIGENS1987 · 14 citations