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April 27, 2006Journal of the American Society of NephrologyOpen Access

Adeno-Associated Virus–Mediated CTLA4Ig Gene Transfer Protects MHC-Mismatched Renal Allografts from Chronic Rejection

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Why the study?

Does local delivery of AAV vectors encoding CTLA4Ig prevent chronic rejection in fully MHC-mismatched rat renal allografts?

Population

fully MHC-mismatched rat strain combination undergoing renal transplantation

Design

Preclinical

Follow-up

up to 120 days

Authors

ABAriela BenigniMario Negri Institute for Pharmacological ResearchSTSusanna TomasoniMario Negri Institute for Pharmacological ResearchLTLaurence A. TurkaBoston University

Discussion

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Implication

Should not yet alter transplant practice; hypothesis-generating for AAV CTLA4Ig tolerance induction in human allografts.

Structured PICO

Does local delivery of AAV vectors encoding CTLA4Ig prevent chronic rejection in fully MHC-mismatched rat renal allografts?

P
Population
fully MHC-mismatched rat strain combination undergoing renal transplantation
I
Intervention
local delivery of recombinant adeno-associated virus (AAV) vectors encoding the CTLA4Ig immunosuppressant protein to the donor kidney
O
Outcome
chronic allograft rejection (progressive proteinuria and renal structural injury)surrogate

AAV-mediated CTLA4Ig gene transfer to donor grafts prevents chronic rejection and induces tolerance in a rat renal transplant model.

Cite This Study

Benigni et al. (2006) studied this question.

synapsesocial.com/papers/6a1d1f93ba65f5ee325dd798https://doi.org/10.1681/asn.2006010090
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tolerance to Cardiac Allografts Via Local and Systemic Mechanisms After Adenovirus-Mediated CTLA4Ig Expression2000 · 93 citations
  2. 2Recombinant adeno-associated virus vectors for gene therapy2004 · 50 citations
  3. 3Generation of Antigen-Specific, Foxp3-Expressing CD4+ Regulatory T Cells by Inhibition of APC Proteosome Function2005 · 49 citations
  4. 4Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses1995 · 1,036 citations
  5. 5Angiotensin converting enzyme inhibition in chronic allograft nephropathy2002 · 76 citations