Why the study?
Does AAV-CTLA4Ig gene transduction prolong allograft survival in mouse cardiac grafts?
Population
B10 (H2(b)) mouse cardiac grafts transplanted into C3H (H2(k)) recipients
Comparison
AAV-CTLA4Ig gene transduction by coronary infusion vs AAV-LacZ vectors
Design
Preclinical
Authors
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Hypothesis-generating for AAV-CTLA4-Ig in murine cardiac allografts; leaves open translation to clinical transplantation.
Does AAV-CTLA4Ig gene transduction prolong allograft survival in mouse cardiac grafts?
AAV-mediated CTLA4Ig gene transfer to donor hearts significantly prolongs allograft survival in a mouse model, suggesting a potential approach to prevent rejection.
Chen et al. (2003) studied this question.
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