Key result
Adenovirus-mediated PD-L1.Ig gene transfer significantly prolonged median cardiac allograft survival to 17 days compared to 11 and 9 days for controls (P < 0.001).
Why the study?
Does adenovirus-mediated PD-L1.Ig gene transfer prolong cardiac allograft survival in a rat model?
Population
F344 rat donor hearts placed in the abdominal position in Lewis recipients
Comparison
Adenovirus-mediated PD-L1.Ig gene transfer vs Noncoding adenovirus or virus dilution buffer…
Design
Preclinical
Follow-up
up to 42 days
Authors
Loading...
Supports PD-L1 gene therapy investigation in transplant models; leaves open translation to human cardiac allograft survival.
Does adenovirus-mediated PD-L1.Ig gene transfer prolong cardiac allograft survival in a rat model?
Absolute Event Rate: 17% vs 11%
p-value: p=< 0.001
Localized PD-L1.Ig gene transfer attenuates acute cardiac allograft rejection in a rat model, with additive effects when combined with subtherapeutic cyclosporin A.
Dudler et al. (2006) studied Cardiac allograft rejection. Adenovirus-mediated PD-L1.Ig gene transfer vs. Noncoding adenovirus or virus dilution buffer alone was evaluated on Median survival time (p=< 0.001). Adenovirus-mediated PD-L1.Ig gene transfer significantly prolonged median cardiac allograft survival to 17 days compared to 11 and 9 days for controls (P < 0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: