Why the study?
Does Angiotensin-(1-7) inhibit Angiotensin II-induced vascular smooth muscle cell proliferation and migration?
Does Angiotensin-(1-7) inhibit Angiotensin II-induced vascular smooth muscle cell proliferation and migration?
Angiotensin-(1-7) counteracts the pro-atherosclerotic effects of Angiotensin II by inhibiting vascular smooth muscle cell proliferation and migration via ERK1/2 pathway modulation.
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Hypothesis-generating for Ang-(1-7) in atherosclerosis; leaves open translation from animal SMC models to human disease.
Zhang et al. (2010) studied this question.
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