Why the study?
Does the molecular weight of Class I antiarrhythmic drugs determine the kinetics of their effects on the maximum rate of depolarization in guinea-pig ventricles?
Population
Guinea-pig ventricle tissue
Design
Preclinical
Authors
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Molecular weight predicts Class I antiarrhythmic block kinetics in guinea-pig ventricle; leaves open translation to human sodium-channel effects.
Does the molecular weight of Class I antiarrhythmic drugs determine the kinetics of their effects on the maximum rate of depolarization in guinea-pig ventricles?
The molecular weight of Class I antiarrhythmic drugs plays a central role in determining the kinetics of their interaction with the fast sodium channel in guinea-pig ventricles.
Terence J. Campbell (1983) studied this question.
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