Key result
Both CCI 22277 and Org 6001 produced rate-dependent block of Vmax in guinea-pig ventricular action potentials and shifted the steady-state inactivation curve in the hyperpolarizing direction.
Population
Guinea-pig ventricle
Design
Preclinical
Authors
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Should not change clinical practice; leaves open antiarrhythmic potential pending mammalian and human studies.
CCI 22277 and Org 6001 demonstrate rate-dependent block of Vmax and selective depression of depolarized cells in guinea-pig ventricular tissue.
Terence J. Campbell (1982) studied this question. CCI 22277 and Org 6001 was evaluated on Maximum rate of depolarization (Vmax). Both CCI 22277 and Org 6001 produced rate-dependent block of Vmax in guinea-pig ventricular action potentials and shifted the steady-state inactivation curve in the hyperpolarizing direction.
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