Key result
Flecainide and lorcainide produced rate-dependent block of the maximum rate of depolarisation with long recovery time constants (15.5 +/- 0.5s and 13.2 +/- 1.3s) in guinea-pig ventricles.
Population
Guinea-pig ventricle
Design
Preclinical
Authors
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May explain class Ic effects in ischaemia; hypothesis-generating and requires human validation.
Flecainide and lorcainide exhibit long recovery times from rate-dependent block and selectively depress depolarised cells, providing a mechanistic explanation for their effects on normal sinus beats and potential relevance in ischaemic states.
Campbell et al. (1983) studied this question. Flecainide and lorcainide was evaluated on Maximum rate of depolarisation (Vmax). Flecainide and lorcainide produced rate-dependent block of the maximum rate of depolarisation with long recovery time constants (15.5 +/- 0.5s and 13.2 +/- 1.3s) in guinea-pig ventricles.
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