Key result
Flecainide interacts with cardiac sodium channels preferentially in the activated state, with unblocking occurring via two separate pathways involving activated and closed states.
Population
Guinea pig single cardiac cells
Design
Preclinical
Authors
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Refines flecainide sodium-channel state dependence; extends mechanistic models but leaves open clinical translation from animal data.
Flecainide blocks cardiac sodium channels primarily in the activated state, with recovery kinetics dependent on both voltage-dependent fast unblocking and voltage-independent slow unblocking pathways.
Anno et al. (1990) studied Guinea pig cardiac cells (in vitro). Flecainide was evaluated on Sodium channel availability and recovery kinetics. Flecainide interacts with cardiac sodium channels preferentially in the activated state, with unblocking occurring via two separate pathways involving activated and closed states.
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