November 1, 1988Circulation ResearchOpen Access

Evidence for two components of sodium channel block by lidocaine in isolated cardiac myocytes.

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Population

Cardiac myocytes isolated from cat and guinea pig

Design

Preclinical

Authors

Discussion

Refines lidocaine's state-dependent sodium block model; leaves open clinical translation from animal data.

Population

Cardiac myocytes isolated from cat and guinea pig

Intervention

Lidocaine (43-200 microM)

Outcome

Sodium current during repetitive depolarizing pulses and time course of block developmentsurrogate

Lidocaine blocks cardiac sodium channels in a use-dependent manner by interacting with both activated and inactivated channel states.

Clarkson et al. (1988) studied this question.

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