March 1, 1991Circulation Research

Two components of use-dependent block of Na+ current by disopyramide and lidocaine in guinea pig ventricular myocytes.

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Population

Isolated guinea pig ventricular myocytes

Comparison

Disopyramide and lidocaine (and QX-314) vs Different pH levels, pulse durations, and…

Design

Preclinical

Authors

АСА. Н. СунамиKobe Tokiwa University JNJunichi NittaSakakibara Hospital MHMasayasu HiraokaElectrophysiology

Discussion

Member takes

Implication

Extends models of activated-state Na channel binding by class I agents; leaves open translation to clinical antiarrhythmic effects.

Structured PICO

Population

Isolated guinea pig ventricular myocytes

Intervention

Disopyramide and lidocaine (and QX-314)

Comparator

Different pH levels (6.5, 7.3, 8.0), pulse durations (5-200 msec), and holding potentials

Outcome

Kinetics of use-dependent block of the Na+ current (INa) and amplitude of fast (Af) and slow (As) componentssurrogate

Disopyramide and lidocaine block cardiac sodium channels via two components (fast and slow), corresponding to the binding of uncharged and charged drug forms to the activated channel state.

Cite This Study

Сунами et al. (1991) studied this question.

synapsesocial.com/papers/6a87c6e4f8efd6d7e4fb1238 https://doi.org/10.1161/01.res.68.3.653

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Two components of use-dependent block of Na+ current by disopyramide and lidocaine in guinea pig ventricular myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Two components of use-dependent block of Na+ current by disopyramide and lidocaine in guinea pig ventricular myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider