Population
Voltage-clamped Xenopus oocytes and cultured cells expressing wild-type and mutant rat skeletal muscle…
Design
Preclinical
Authors
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No immediate clinical implications from this animal study; extends mechanistic evidence for P-loop involvement in sodium modulation of lidocaine block.
Lidocaine binding induces sodium channels to occupy a native slow inactivated state that is inhibited by extracellular sodium.
Chen et al. (2000) studied this question.
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