September 1, 1988CirculationOpen Access

Competition between lidocaine and one of its metabolites, glycylxylidide, for cardiac sodium channels.

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Population

Single, voltage-clamped cardiocytes

Comparison

Lidocaine and its metabolite glycylxylidide (GX) vs Lidocaine alone or GX alone

Design

Preclinical

Authors

PBPaul B. BennettPiri Reis University RWRaymond L. WoosleyElectrophysiology LHLuc M. HondeghemFlanders Marine Institute

Discussion

Member takes

Implication

May explain variable lidocaine efficacy during ischemia; leaves open translation of modulated receptor hypothesis to human myocardium.

Structured PICO

Population

Single, voltage-clamped cardiocytes

Intervention

Lidocaine and its metabolite glycylxylidide (GX)

Comparator

Lidocaine alone or GX alone

Outcome

Blockade of cardiac sodium channels and kinetics of recoverysurrogate

Lidocaine and its metabolite GX compete for the same cardiac sodium channel receptor, which can paradoxically reduce channel blockade when both are present under certain voltage conditions.

Cite This Study

Bennett et al. (1988) studied this question.

synapsesocial.com/papers/6a89b501b4e829b19bd45be9 https://doi.org/10.1161/01.cir.78.3.692

View Full Paper

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Bookmark

Competition between lidocaine and one of its metabolites, glycylxylidide, for cardiac sodium channels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Competition between lidocaine and one of its metabolites, glycylxylidide, for cardiac sodium channels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider