Key result
Nine Class I anti-arrhythmic drugs were subdivided into three distinct subclasses (fast, intermediate, and slow) based on the speed of onset of rate-dependent depression of Vmax and APD.
Population
Guinea-pig ventricle
Design
Preclinical
Authors
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Hypothesis-generating subclassification of Class I agents by onset kinetics; leaves open translation to human arrhythmias.
Class I antiarrhythmic drugs can be subclassified into three distinct groups based on their kinetics of onset of rate-dependent Vmax depression and effects on action potential duration in guinea-pig ventricles.
Terence J. Campbell (1983) studied Class I antiarrhythmic drug effects on guinea-pig ventricle. Nine Class I anti-arrhythmic drugs (lignocaine, tocainide, mexiletine, quinidine, disopyramide, procainamide, flecainide, encainide, lorcainide) vs. Compared to each other was evaluated on Kinetics of onset of rate-dependent depression of maximum rate of depolarisation (Vmax) and effects on effective refractory period (ERP) relative to action potential duration (APD). Nine Class I anti-arrhythmic drugs were subdivided into three distinct subclasses (fast, intermediate, and slow) based on the speed of onset of rate-dependent depression of Vmax and APD.
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