Why the study?
Do encainide metabolites ODE and MODE depress the maximum rate of depolarization in guinea-pig ventricular myocardium and dog Purkinje fibres?
Do encainide metabolites ODE and MODE depress the maximum rate of depolarization in guinea-pig ventricular myocardium and dog Purkinje fibres?
The major metabolites of encainide, ODE and MODE, produce significant rate-dependent depression of Vmax, which may contribute to both their antiarrhythmic and proarrhythmic effects.
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May contribute to encainide's anti- and proarrhythmic effects; leaves open human translation from animal models.
Hemsworth et al. (1989) studied this question.
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