In vivo anti-inflammatory effects of Prasiola japonica ethanol extract

This is the authors' abstract. We don't add key points for this paper.

The aim of this study was to investigate the efficacy of Prasiola japonica ethanol extract (Pj-EE) in various mouse inflammation models. For edema mice models, eight-week-old female ICR mice were orally administrated with Pj-EE (25 and 50 mg/kg) for one week, before ear edema induction with carrageenan or xylene. The weight, thickness, and volume of paw and ear edema were decreased in Pj-EE-treated mice after 3 h of edema induction. The mRNA expression levels of iNOS, COX-2, IL-6, IL-1β, and IFN-γ were decreased in Pj-EE-treated conditions. The phosphorylation forms of IκBα and IKKα/β were suppressed by Pj-EE at 50 mg/kg. The effect of Pj-EE on gastrointestinal disorder was examined in HCl/EtOH-induced gastritis model. Oral administration of Pj-EE ameliorated HCl/EtOH-stimulated gastric ulcers. In addition, Pj-EE reduced gene expressions of iNOS, COX-2, IL-6, and IL-1β. Alverine, one of ingredient compounds in Pj-EE, was also confirmed to show anti-edema activity, in vitro, and in vivo. Conclusively, therapeutic effects of Pj-EE were demonstrated in various inflammatory mouse models, suggesting a possibility as a promising anti-inflammatory functional food.