Why the study?
High dietary salt exaggerates hypertension across multiple experimental models, but its specific effects on vascular dysfunction and aortic stiffness in renovascular hypertension were evaluated.
Does a high-salt diet increase arterial blood pressure and aortic stiffness in a murine model of renovascular hypertension?
Does a high-salt diet increase arterial blood pressure and aortic stiffness in a murine model of renovascular hypertension?
High dietary salt interacts with underlying renovascular hypertension to promote selective vascular dysfunction and aortic stiffness in mice.
High dietary salt exaggerates hypertension in multiple experimental models. Here we demonstrate that a high-salt diet produces a greater increase in arterial blood pressure at 1 wk after induction of 2-kidney, 1-clip (2K1C) hypertension but not at 3 wk. Interestingly, 2K1C mice fed a high-salt diet displayed an exaggerated pulse pressure, elevated pulse wave velocity, and reduced endothelium-dependent vasodilation of the aorta but not mesenteric arteries. These findings suggest that dietary salt may interact with underlying cardiovascular disease to promote selective vascular dysfunction and aortic stiffness.
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DeLalio et al. (2020) studied 2-kidney, 1-clip (2K1C) hypertension. High-salt diet was evaluated on Arterial blood pressure, pulse pressure, pulse wave velocity, and endothelium-dependent vasodilation.
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