Key result
Hypertrophic cardiomyopathy was associated with significant mitochondrial hyperplasia, characterized by a 39.28% decrease in average mitochondrial area and an increased number of mitochondria per field of view.
Population
20 patients with diffuse-generalized phenotype HCM and 2 control patients operated for aortic valve stenosis
Comparison
Intraoperative interventricular septum myocardial biopsies from diffuse-generalized HCM vs aortic valve stenosis controls
Design
Transmission electron microscopy observational study
Authors
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Ultrastructural HCM findings are hypothesis-generating; larger studies needed to link to arrhythmias or mitochondrial changes.
Observational (n=22)
Yes
Absolute Event Rate: 0.173% vs 0.2849%
p-value: p=≤0.0005
Myocardial mitochondria in diffuse-generalized hypertrophic cardiomyopathy exhibit ultrastructural changes indicative of compensatory hyperplasia and chronic hypoxia.
Kozlova et al. (2024) conducted an observational in Hypertrophic cardiomyopathy (diffuse-generalized phenotype) (n=22). Hypertrophic cardiomyopathy vs. Aortic valve stenosis with working myocardial hypertrophy was evaluated on Average area of mitochondria (µm²) (p=≤0.0005). Hypertrophic cardiomyopathy was associated with significant mitochondrial hyperplasia, characterized by a 39.28% decrease in average mitochondrial area and an increased number of mitochondria per field of view.
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