Key result
Sublingual nitroglycerin abolishes cocaine-induced coronary vasoconstriction in both diseased and non-diseased artery segments.
Why the study?
Cocaine causes coronary vasoconstriction, particularly in diseased segments, but the effect of nitroglycerin on this vasoconstriction required assessment.
Does sublingual nitroglycerin alleviate cocaine-induced coronary vasoconstriction in patients with coronary artery disease?
Population
23 patients aged 43 to 65 years
Comparison
Sublingual nitroglycerin vs sublingual placebo after cocaine
Authors
Loading...
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“Most cocaine-related chest pains are due to the fact that the blood vessels have been constricted. The most effective treatment for this is nitroglycerin or calcium blockers.”
Nitroglycerin may relieve cocaine-related ischemia; leaves open larger trials to guide practice.
Does sublingual nitroglycerin alleviate cocaine-induced coronary vasoconstriction in patients with coronary artery disease?
Sublingual nitroglycerin effectively reverses cocaine-induced coronary vasoconstriction, providing a physiological rationale for its use in cocaine-associated myocardial ischemia.
Brogan et al. (1991) studied Coronary artery disease (n=23). Nitroglycerin vs. Sublingual placebo was evaluated on Reversal of cocaine-induced coronary vasoconstriction. Sublingual nitroglycerin abolished cocaine-induced coronary vasoconstriction in both non-diseased and diseased coronary artery segments.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: