Key result
Current of injury during leadless pacemaker implantation is linked to acutely improved 5-minute capture thresholds.
Why the study?
Current of injury predicts stability and acute electrical improvement in transvenous leads, but its periprocedural value in leadless pacemakers was unknown.
Does the presence of current of injury predict acute reduction in pacing threshold and adequate fixation in patients undergoing leadless pacemaker implantation?
Cohort (n=51)
Does the presence of current of injury predict acute reduction in pacing threshold and adequate fixation in patients undergoing leadless pacemaker implantation?
p-value: p=0.002
Current of injury during leadless pacemaker implantation is a useful periprocedural marker for adequate fixation and acute improvement in capture threshold.
May aid periprocedural LLP assessment; extends transvenous COI data but remains hypothesis-generating.
Background Current of injury (COI) predicts stability and acute improvement in electrical parameters in transvenous pacing or high‐voltage leads; however, the periprocedural value of this marker in leadless pacemakers (LLPs) is unknown. Methods From March 2021 to October 2022, 66 consecutive Micra LLP pacemaker candidates were enrolled. Electrograms (EGMs) and electrical measures were acquired immediately after the deployment and 5 min after. The primary outcomes were an acute reduction in pacing threshold and, conversely, a need for device repositioning. Results Fifty‐one patients were included in the final analysis after excluding poor‐quality EGMs and pacemaker‐dependent cases ( n = 15). COI was identified in 32 (62%). There were no differences in the initial electrical measures between the COI+ and COI− groups ( p value = 0.33, 0.37, 0.89 for impedance, pacing threshold, and sensing, respectively). Notably, the capture threshold significantly improved only in the COI+ group within 5 min ( p = 0.002). A subgroup analysis of COI+ revealed that the saddleback type of injury (Type 2) was associated with a more significant acute reduction in the capture threshold ( p = 0.02). Repositioning occurred in three subjects, and acute dislodgment at the tug‐test occurred in two patients, all from the COI– group. Conclusions COI is associated with an acute improvement of capture threshold, particularly when a Type 2 pattern is noted. The absence of injury, in contrast, could reflect inadequate fixation and a need for repositioning.
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Tarantino et al. (2026) conducted a cohort in Micra leadless pacemaker candidates (n=51). Current of injury (COI) vs. Absence of COI (COI-) was evaluated on Acute reduction in pacing threshold and need for device repositioning (p=0.002). The presence of current of injury during leadless pacemaker implantation was associated with a significant acute improvement in capture threshold within 5 minutes (p=0.002).
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