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August 10, 2026Bioprocess and Biosystems EngineeringOpen Access

Simulating large-scale biotech bubble columns: challenges and insights from the parcel approach

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Authors

CLCarolin LinkLPLars PuimanRTRalf Takors

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Overview

Randomized trial illustrates the potential and limitations of parcel-based modeling in large-scale bioreactors, indicating practical insights for design.

Key Points

  • The aim is to explore computational modeling techniques for large-scale bioreactors, focusing on the parcel approach in gas fermentation.
  • Applied Lattice Boltzmann large eddy simulations to evaluate bubble dynamics.
  • Utilized Euler-Lagrange approaches for detailed local resolution in simulations.
  • Compared findings with finite-volume Reynolds-averaged Navier-Stokes simulations to assess performance.
  • Observed swarm-like bubble behavior leading to inhomogeneous bubble distributions.
  • Found deviations in volumetric mass transfer coefficient k L a due to the parcel size approach.
  • Identified similarities in transient flow structures and averaged velocity values between both simulation methods.

Cite This Study

Link et al. (2026) studied this question.

synapsesocial.com/papers/6a7999219c20a9bbd3184d5ehttps://doi.org/10.1007/s00449-026-03397-5
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