What question did this study set out to answer?

To determine whether lysophosphatidic acid (LPA) induces itch-scratch responses in mice and to identify the underlying signaling pathways.

January 1, 2004Pharmacology

Itch-Scratch Responses Induced by Lysophosphatidic Acid in Mice

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Authors

THTerumasa HashimotoShowa University HOHisayuki OhataNippon Medical School KMKazutaka MomoseShowa University

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Implication

Animal experiment demonstrates that lysophosphatidic acid evokes itch-scratch responses in mice, suggesting involvement of histamine, substance P, and Rho-kinase signaling pathways.

Key Points

To determine whether lysophosphatidic acid (LPA) induces itch-scratch responses in mice and to identify the underlying signaling pathways.
Administered intradermal injections of lysophosphatidic acid, histamine, and prostaglandin D2 to evaluate scratching behaviors in mice.
Pretreated mice with ketotifen (histamine H1 receptor antagonist), capsaicin (sensory nerve defunctionalizer), or Y-27632 (Rho-associated kinase inhibitor) before LPA injection.
Intradermal administration of LPA provoked itch-scratch responses following a time course similar to histamine, whereas prostaglandin D2 failed to elicit scratching.
Pretreatment with ketotifen and capsaicin inhibited LPA-induced scratching, while Y-27632 completely abolished the response.

Cite This Study

Hashimoto et al. (2004) studied this question.

synapsesocial.com/papers/6a799a7cfb5b6b43000dbfa5 https://doi.org/10.1159/000078632

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Implication

Animal experiment demonstrates that lysophosphatidic acid evokes itch-scratch responses in mice, suggesting involvement of histamine, substance P, and Rho-kinase signaling pathways.

Itch-Scratch Responses Induced by Lysophosphatidic Acid in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Itch-Scratch Responses Induced by Lysophosphatidic Acid in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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