Key result
A 46-year-old female with bipolar disorder developed sinus bradycardia with a heart rate of 48 beats/min after 5 days of lurasidone 80 mg/day, which resolved upon discontinuation.
Why the study?
While tachycardia and orthostatic hypotension are recognized cardiovascular complications of antipsychotics, this report presents a case of sinus bradycardia caused by the addition of lurasidone.
Case Report (n=1)
No
Lurasidone administration may be associated with the development of sinus bradycardia, highlighting the importance of monitoring heart rate after initial administration.
May warrant heart rate monitoring with lurasidone initiation; leaves open incidence and causality in larger studies.
To date, tachycardia and orthostatic hypotension have been reported as one of the negative cardiovascular complications of antipsychotics. The aim of this study was to report a case of sinus bradycardia caused by the addition of lurasidone. The patient, a 46-year-old bipolar disorder female, was admitted to the Affiliated Brain Hospital of Guangzhou Medical University with 28 years of alternating euphoric and dysphoria. On the basis of lithium carbonate 1,200 mg/day and sodium valproate 1,500 mg/day, the patient was given lurasidone 80 mg/day. After 5 days of medication, her heart rate (HR) became 48 beats per minute (beats/min). As a result, lurasidone treatment was held. On 5th day after discontinuing lurasidone, the HR reached 80 beats/min. This case report notifies that although the cardiovascular effects of lurasidone are not significant, it is also important to monitor HR status after the first administration of lurasidone.
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Kuang et al. (2023) conducted a case report in Bipolar disorder (n=1). Lurasidone vs. Baseline/Discontinuation was evaluated on Heart rate. A 46-year-old female with bipolar disorder developed sinus bradycardia with a heart rate of 48 beats/min after 5 days of lurasidone 80 mg/day, which resolved upon discontinuation.
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