Key result
This review summarizes how cells use ribosome-associated quality control to detect stalled ribosomes, ubiquitylate tethered nascent chains, and deliver them to the proteasome for degradation.
Why the study?
Stalled protein synthesis generates defective nascent chains that can harm cells, prompting ribosome-associated quality control to degrade them.
This review provides a comprehensive overview of the eukaryotic ribosome-associated quality control pathway, detailing how cells manage stalled translation to prevent cellular harm.
Ribosome quality control mechanisms are not yet clinically actionable; leaves open their potential role in cardiac proteostasis or targeted therapies.
Stalled protein synthesis produces defective nascent chains that can harm cells. In response, cells degrade these nascent chains via a process called ribosome-associated quality control (RQC). Here, we review the irregularities in the translation process that cause ribosomes to stall as well as how cells use RQC to detect stalled ribosomes, ubiquitylate their tethered nascent chains, and deliver the ubiquitylated nascent chains to the proteasome. We additionally summarize how cells respond to RQC failure.
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Sitron et al. (2020) conducted a review in Stalled protein synthesis. Ribosome-associated quality control (RQC) was evaluated. This review summarizes how cells use ribosome-associated quality control to detect stalled ribosomes, ubiquitylate tethered nascent chains, and deliver them to the proteasome for degradation.
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