Key result
Antibody, including IgG, plays a critical role in the clearance of murine norovirus infection both systemically and in the intestine.
Why the study?
Does the transfer of virus-specific antibodies or immune B cells reduce viral titers in mice infected with murine norovirus?
Population
Wild-type C57BL/6/J, B6RAG1-/-, muMT, and HELMET mice infected with murine norovirus strain MNV1.CW3.
Comparison
Adoptive transfer of immune splenocytes, passive… vs Mock transfer, non-immune splenocytes…
Design
Preclinical
Follow-up
Up to 21 days post-transfer
Authors
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Supports antibody-mediated clearance in murine norovirus models; leaves open translation to human infection.
Does the transfer of virus-specific antibodies or immune B cells reduce viral titers in mice infected with murine norovirus?
B cells and virus-specific IgG antibodies are critical for the clearance of mucosal and systemic murine norovirus infection.
Chachu et al. (2008) studied Murine norovirus infection. B cells and anti-MNV antibodies (adoptive/passive transfer) vs. Wild-type mice, nonimmune splenocytes, or control antibody was evaluated on Clearance of MNV infection (virus titers in distal ileum, MLN, and spleen). Antibody, including IgG, plays a critical role in the clearance of murine norovirus infection both systemically and in the intestine.
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