Key result
Radiation therapy for breast cancer causes long-term damage to all heart structures, with clinically significant radiation-induced heart diseases occurring in 10-30% of patients 5-10 years after treatment.
Why the study?
Radiation therapy for breast cancer causes long-term heart damage that worsens quality of life and increases cardiac death risk, highlighting the need to analyze long-term cardiac changes resulting from radiation therapy.
Population
Patients with breast cancer receiving radiation therapy
Design
Analysis of long-term studies
Authors
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May warrant enhanced cardiac surveillance in survivors; leaves open optimal dose constraints and cardioprotection for prospective trials.
Radiation therapy for breast cancer is associated with a significant long-term risk of cardiovascular damage and mortality, driven by endothelial and mitochondrial dysfunction.
Bаzyка et al. (2022) conducted a review in Breast cancer. Radiation therapy was evaluated. Radiation therapy for breast cancer causes long-term damage to all heart structures, with clinically significant radiation-induced heart diseases occurring in 10-30% of patients 5-10 years after treatment.
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