Why the study?
Do oral contraceptives increase the risk of venous thromboembolism, myocardial infarction, and ischaemic stroke in women?
Do oral contraceptives increase the risk of venous thromboembolism, myocardial infarction, and ischaemic stroke in women?
Oral contraceptives increase the risk of thrombotic and cardiovascular events, highlighting the importance of personal predisposing factors and age-related vascular risks when prescribing.
Answers are grounded in this paper and cite their sources.
May inform risk-stratified contraceptive counseling; leaves open the need for prospective data on modern formulations.
The risks of venous thromoembolism, myocardial infarction and ischaemic stroke are increased in oral contraceptive users, even with oral contraceptives with ≤35 μg of oestrogen. Personal predisposing factors are more relevant than the particular type of progestagen incorporated into the oral contraceptive. Evidence of the relative safety of second generation compared with third generation oral contraceptives for venous thromboembolism may be distorted by bias in the relevant studies. Recent evidence shows that the risk of myocardial infarction or stroke in women on modern oral contraceptives appears to be confined to the older age group, especially those with other vascular risk factors.
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Dunn et al. (1998) studied this question.
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