Why the study?
Does hormonal contraception increase the risk of thrombotic stroke and myocardial infarction in nonpregnant women aged 15 to 49 years?
Population
1,626,158 nonpregnant women, 15 to 49 years old, with no history of cardiovascular disease or cancer.
Comparison
Hormonal contraception, including oral… vs Nonusers of hormonal contraceptives.
Design
Cohort
Follow-up
15-year period (1995-2009) totaling 14,251,063 person-years
Authors
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May increase arterial thrombotic risk dose-dependently; leaves open whether 20 μg formulations meaningfully improve safety in young women.
Does hormonal contraception increase the risk of thrombotic stroke and myocardial infarction in nonpregnant women aged 15 to 49 years?
While the absolute risk remains low, the use of hormonal contraception is associated with a significantly increased relative risk of thrombotic stroke and myocardial infarction, which scales with ethinyl estradiol dose.
Lidegaard et al. (2012) studied this question.
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