September 25, 1964Science
Reduction of Cardiac Stores of Norepinephrine in Experimental Heart Failure
Population
Guinea pigs with experimental heart failure induced by constriction of the ascending aorta
Design
Preclinical
Follow-up
5 to 40 days
Authors
Discussion
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Implication
May reflect sympathetic changes in experimental HF; leaves open clinical relevance or therapeutic targeting in patients.
Structured PICO
P
Population
Guinea pigs with experimental heart failure induced by constriction of the ascending aorta
I
Intervention
Constriction of the ascending aorta
O
Outcome
Norepinephrine stores in both ventriclessurrogate
Experimental heart failure in guinea pigs is associated with a significant, severity-dependent depletion of ventricular norepinephrine stores.
Cite This Study
Spann et al. (1964) studied this question.