What question did this study set out to answer?

To determine the role of catecholamines in cardiac failure by assessing their urinary excretion in patients with acquired valvular disease.

January 1, 1963Japanese Heart JournalOpen Access

Catecholamine in Congestive Heart Failure (Report I)

View Full Paper

Ask AI

Bookmark

Population

178 patients with congestive cardiac failure suffering from acquired valvular disease, admitted to Kobe…

Design

Cohort

Authors

TTTatsuya TomomatsuKobe Medical Center YUYasuyuki UebaCentral Clinical Hospital TMTetsuo MatsumotoTokyo Institute of Technology

Discussion

Member takes

Implication

Urinary catecholamines were associated with valvular HF severity and status changes; leaves open their role as dynamic biomarkers pending prospective studies.

Key Points

To determine the role of catecholamines in cardiac failure by assessing their urinary excretion in patients with acquired valvular disease.
Measured urinary adrenaline and noradrenaline levels in 178 patients with congestive heart failure.
Patients were classified into four groups based on New York Heart Association criteria.
Collected urine samples every 5 to 6 hours during rapid digitalization for analysis.
Urinary adrenaline and noradrenaline levels increased from grade I to grade III heart failure, then decreased in grade IV but remained elevated.
Enhancements in clinical condition from grade IV to III showed increased catecholamine excretion, while worsening conditions led to inverse changes.
Significant variations in urinary active catechols reflect changes in heart failure severity.

Structured PICO

Population

178 patients with congestive cardiac failure suffering from acquired valvular disease, admitted to Kobe Medical College Hospital, divided into four groups according to New York Heart Association criteria.

Outcome

Urinary excretion of adrenaline and noradrenalinesurrogate

Urinary catecholamine excretion correlates with the severity of congestive heart failure, peaking at NYHA class III and fluctuating with changes in clinical status.

Cite This Study

Tomomatsu et al. (1963) studied this question.

synapsesocial.com/papers/6a70bb41b27f158178277e27 https://doi.org/10.1536/ihj.4.13

Topics

Heart failure HFrEF treatment Heart failure hospitalization

View Full Paper

Ask AI

Bookmark

Implication

Urinary catecholamines were associated with valvular HF severity and status changes; leaves open their role as dynamic biomarkers pending prospective studies.

Catecholamine in Congestive Heart Failure (Report I)

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Catecholamine in Congestive Heart Failure (Report I)

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider