What question did this study set out to answer?

To measure the urinary excretion of adrenaline and catechol derivatives in healthy individuals, patients with essential hypertension, and patients with myocardial infarction.

January 1, 1953CirculationOpen Access

The Urinary Output of Catechol Derivatives Including Adrenaline in Normal Individuals, in Essential Hypertension, and in Myocardial Infarction

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Why the study?

Does the urinary output of catechol derivatives differ among normal individuals, patients with essential hypertension, and patients with myocardial infarction?

Population

Normal individuals, patients with essential hypertension, and patients with myocardial infarction

Comparison

Measurement of urinary catechol derivatives… vs Normal individuals and von Euler technic

Design

Cross-sectional

Authors

FNFranklin R. NuzumSanta Barbara Cottage Hospital FBFritz BischoffSanta Barbara Cottage Hospital

Discussion

Member takes

Implication

Does not confirm catechol ratio elevation in essential hypertension but indicates possible elevation in myocardial infarction; challenges prior reports and leaves diagnostic value open.

Key Points

To measure the urinary excretion of adrenaline and catechol derivatives in healthy individuals, patients with essential hypertension, and patients with myocardial infarction.
Quantified urinary adrenaline levels using Shaw's specific test and compared results to historic benchmarks from the von Euler bioassay method.
Evaluated the Kroneberg-Schümann catechol ratio across normal subjects, patients with essential hypertension, and patients with myocardial infarction.
Urinary adrenaline excretion measured by Shaw's test was notably higher in some normal individuals compared to previously reported bioassay techniques.
Patients with myocardial infarction demonstrated marked elevations in the Kroneberg-Schümann catechol ratio across three cases and significantly elevated adrenaline levels across four measurements in one patient.
The previously reported elevation of the Kroneberg-Schümann catechol ratio in essential hypertension compared to normal controls was not confirmed.

Structured PICO

Does the urinary output of catechol derivatives differ among normal individuals, patients with essential hypertension, and patients with myocardial infarction?

Population

Normal individuals, patients with essential hypertension, and patients with myocardial infarction

Intervention

Measurement of urinary catechol derivatives (including adrenaline) using Shaw's specific test

Comparator

Normal individuals (for disease groups) and von Euler technic (for assay comparison)

Outcome

Urinary adrenaline content and Kroneberg-Schümann catechol ratiosurrogate

Urinary catechol ratios may be elevated in myocardial infarction but not necessarily in essential hypertension, challenging previous reports.

Cite This Study

Nuzum et al. (1953) studied this question.

synapsesocial.com/papers/6a71b8402163a0a01bc5bf27 https://doi.org/10.1161/01.cir.7.1.96

Topics

Hypertension management

View Full Paper

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Implication

Does not confirm catechol ratio elevation in essential hypertension but indicates possible elevation in myocardial infarction; challenges prior reports and leaves diagnostic value open.

The Urinary Output of Catechol Derivatives Including Adrenaline in Normal Individuals, in Essential Hypertension, and in Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

The Urinary Output of Catechol Derivatives Including Adrenaline in Normal Individuals, in Essential Hypertension, and in Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider