Key result
Higher urinary adrenaline in HF is linked to a ~2-fold increase in complex ventricular arrhythmias.
Why the study?
The role of elevated adrenaline levels in congestive heart failure and their association with clinical severity and arrhythmias was not known.
Population
49 patients with exacerbation of CHF NYHA class II-III
Comparison
Patients with normal vs increased urinary excretion of adrenaline
Design
Observational study
Authors
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May identify higher-risk CHF patients; hypothesis-generating for arrhythmia risk stratification, no practice change yet.
Observational (n=49)
Absolute Event Rate: 74% vs 37%
Increased urinary adrenaline excretion in CHF patients identifies a subgroup with more advanced disease, larger LV dimensions, and more frequent ventricular arrhythmias.
Grochowicz et al. (2001) conducted an observational in Congestive heart failure (n=49). Increased urinary excretion of adrenaline vs. Normal urinary excretion of adrenaline was evaluated on Presence of complex ventricular arrhythmias. Increased urinary excretion of adrenaline in heart failure patients was associated with greater left ventricular end-diastolic dimension (p<0.05) and more complex ventricular arrhythmias (74% vs 37%).
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