What question did this study set out to answer?

To determine whether intrinsic mechanical defects exist in the isolated contractile proteins of heart muscle during chronic congestive heart failure.

January 1, 1958Circulation ResearchOpen Access

Contractile Properties of Glycerol-Extracted Muscle Bundles from the Chronically Failing Canine Heart

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Why the study?

Does chronic congestive heart failure alter the contractile properties of glycerol-extracted muscle bundles in dogs?

Population

Dogs with chronic congestive heart failure induced by surgical production of tricuspid insufficiency and…

Comparison

Glycerol-extracted trabecular bundles from the… vs Glycerol-extracted trabecular bundles from the…

Design

Preclinical

Authors

EBEllis S. BensonRegions Hospital BHBen E. HallawayUniversity of Minnesota CTCharles E. TurbakRegions Hospital

Discussion

Member takes

Implication

May implicate intrinsic actomyosin defects in canine HF; hypothesis-generating for human mechanisms and therapies.

Key Points

To determine whether intrinsic mechanical defects exist in the isolated contractile proteins of heart muscle during chronic congestive heart failure.
Induced chronic congestive heart failure surgically in canines through tricuspid insufficiency and pulmonary stenosis.
Prepared glycerol-extracted trabecular bundles from both ventricles of normal and failing hearts to isolate contractile elements from membrane, neurohormonal, and metabolic influences.
Measured isometric tension development, maximum working capacity, and the rate of adenosinetriphosphate hydrolysis in the isolated muscle bundles.
Trabecular bundles from failing right and left ventricles generated significantly less tension and had lower maximum working capacity than those from normal hearts.
The rate of adenosinetriphosphate hydrolysis in failing heart preparations remained equal to that of normal heart controls.

Structured PICO

Does chronic congestive heart failure alter the contractile properties of glycerol-extracted muscle bundles in dogs?

Population

Dogs with chronic congestive heart failure induced by surgical production of tricuspid insufficiency and pulmonary stenosis

Intervention

Glycerol-extracted trabecular bundles from the right and left ventricles

Comparator

Glycerol-extracted trabecular bundles from the hearts of normal dogs

Outcome

Tension development and maximum working capacitysurrogate

Defective contractility in failing hearts may be ascribed to physiochemical changes in the contractile protein actomyosin, independent of membrane or neurohormonal effects.

Cite This Study

Benson et al. (1958) studied this question.

synapsesocial.com/papers/6a79a7c014b028facf0de7fd https://doi.org/10.1161/01.res.6.1.122

Topics

Heart failure HFrEF treatment

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Contractile Properties of Glycerol-Extracted Muscle Bundles from the Chronically Failing Canine Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Contractile Properties of Glycerol-Extracted Muscle Bundles from the Chronically Failing Canine Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider