Key result
Heart V5 radiation dose during left whole breast radiotherapy was significantly associated with an early increase of ≥30% in high-sensitivity cardiac troponin T (HR 3.75).
Why the study?
Hs-cTnT may have predictive value for myocardial damage during radiotherapy for left-sided breast cancer, but its early response and correlation with pre-existing factors needed evaluation.
Does adjuvant left whole breast radiotherapy increase serum Hs-cTnT levels in patients with early stage left-sided breast cancer?
Observational (n=45)
Does adjuvant left whole breast radiotherapy increase serum Hs-cTnT levels in patients with early stage left-sided breast cancer?
Hazard Ratio: 3.75 (95% CI 0.9–14.8)
p-value: p=<0.005
Adjuvant left whole breast radiotherapy increases high-sensitivity cardiac troponin T levels in about a quarter of patients, which correlates significantly with the volume of the heart receiving 5 Gy (V5).
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Heart V5 may flag early cardiac injury risk in left breast radiotherapy; hypothesis-generating for dose-optimization trials.
CIRNIGLIARO et al. (2023) conducted an observational in Early stage left-sided breast cancer (n=45). Heart V5 radiation dose during left whole breast radiotherapy was evaluated on Increase in high-sensitivity cardiac troponin T (Hs-cTnT) of ≥30% from baseline (HR 3.75, 95% CI 0.9-14.8, p=<0.005). Heart V5 radiation dose during left whole breast radiotherapy was significantly associated with an early increase of ≥30% in high-sensitivity cardiac troponin T (HR 3.75).
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