What question did this study set out to answer?

To evaluate the performance of the disk diffusion method compared to the CLSI broth microdilution reference standard (M38-A) for determining posaconazole susceptibility in filamentous fungi.

February 22, 2006Antimicrobial Agents and ChemotherapyOpen Access

Evaluation of Disk Diffusion Method for Determining Posaconazole Susceptibility of Filamentous Fungi: Comparison with CLSI Broth Microdilution Method

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Authors

ELE. López-OviedoHospital Universitario de Valme AAAna Isabel AllerHospital Universitario de Valme CMCraig A. MartinAlcohol and Drug Foundation

Discussion

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Implication

Comparative laboratory study reveals significant correlation between disk diffusion and microdilution for posaconazole in molds, indicating disk diffusion provides a reliable alternative.

Key Points

To evaluate the performance of the disk diffusion method compared to the CLSI broth microdilution reference standard (M38-A) for determining posaconazole susceptibility in filamentous fungi.
Tested posaconazole susceptibility across 78 strains of molds.
Evaluated disk diffusion performance using two different culture media in direct comparison with the CLSI M38-A broth microdilution method.
Observed a statistically significant correlation between the disk diffusion and broth microdilution methods across tested strains.
Maintained consistent correlation between methods on both evaluated culture media.

Cite This Study

López-Oviedo et al. (2006) studied this question.

synapsesocial.com/papers/6a79ac1877336a1bae026ea7 https://doi.org/10.1128/aac.50.3.1108-1111.2006

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Implication

Comparative laboratory study reveals significant correlation between disk diffusion and microdilution for posaconazole in molds, indicating disk diffusion provides a reliable alternative.

Evaluation of Disk Diffusion Method for Determining Posaconazole Susceptibility of Filamentous Fungi: Comparison with CLSI Broth Microdilution Method

Discussion

Member takes

Implication

Key Points

Cite This Study

Evaluation of Disk Diffusion Method for Determining Posaconazole Susceptibility of Filamentous Fungi: Comparison with CLSI Broth Microdilution Method

Discussion

Member takes

Implication

Key Points

Cite This Study

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