Key result
Induction of myocyte hypertrophy in vitro or in vivo leads to an increase in vitamin D receptor mRNA and protein levels.
Population
In vitro and in vivo models of cardiac myocytes, fibroblasts, and intact ventricular myocardium
Design
Preclinical
Authors
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Suggests potential antihypertrophic role for cardiac vitamin D signaling; hypothesis-generating from animal data only.
The key components for a functional 1,25 dihydroxyvitamin D-dependent signaling system are present in the heart and amplified during cardiac hypertrophy, suggesting a potential antihypertrophic role.
Chen et al. (2008) studied Cardiac hypertrophy. Induction of myocyte hypertrophy was evaluated on VDR mRNA and protein levels. Induction of myocyte hypertrophy in vitro or in vivo leads to an increase in vitamin D receptor mRNA and protein levels.
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