Key result
ETS transcription factors regulate angiogenesis and act in a combinatorial fashion with other factors through composite sites to determine endothelial specificity in gene transcription.
This review highlights the role of ETS transcription factors and their combinatorial interactions in regulating endothelial gene expression and angiogenesis.
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Should not yet change clinical practice in angiogenesis-related disease; leaves open targeted ETS research in endothelial gene regulation.
Transcription factors of the ETS family are important regulators of endothelial gene expression. Here, we review the evidence that ETS factors regulate angiogenesis and briefly discuss the target genes and pathways involved. Finally, we discuss novel evidence that shows how these transcription factors act in a combinatorial fashion with others, through composite sites that may be crucial in determining endothelial specificity in gene transcription.
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Randi et al. (2009) conducted a review in Angiogenesis. ETS transcription factors was evaluated. ETS transcription factors regulate angiogenesis and act in a combinatorial fashion with other factors through composite sites to determine endothelial specificity in gene transcription.
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