Key result
Combination therapy with azilsartan medoxomil and chlorthalidone provides superior blood pressure lowering and cardiovascular protection compared to hydrochlorothiazide-based regimens.
Why the study?
Does combination therapy with azilsartan medoxomil and chlorthalidone improve blood pressure reduction and prevent cardiovascular events compared to hydrochlorothiazide or monotherapy in patients with arterial hypertension?
Does combination therapy with azilsartan medoxomil and chlorthalidone improve blood pressure reduction and prevent cardiovascular events compared to hydrochlorothiazide or monotherapy in patients with arterial hypertension?
Combination therapy with azilsartan medoxomil and chlorthalidone offers an effective and rational strategy for blood pressure control and cardiovascular risk reduction in hypertensive patients.
Hypothesis-generating for azilsartan-chlorthalidone combinations; leaves open confirmation in randomized outcome trials.
The article discusses the problem of the use for the treatment of hypertension combination therapy. Advantages of application as a component of chlorthalidone therapy are discussed. Proofs of its effectiveness in lowering both blood pressure and risk of cardiovascular events compared with hydrochlorothiazide are stated. Anti-hypertensive effectiveness of one of the last appeared on the pharmacological market of receptor-blockers like angiotensin II azilsartan medoxomil in combination with chlorthalidone is discussed as well.
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М. Г. Бубнова (2015) conducted a review in Arterial hypertension. Azilsartan medoxomil and chlorthalidone combination therapy vs. Hydrochlorothiazide-based combinations or monotherapy was evaluated. Combination therapy with azilsartan medoxomil and chlorthalidone provides superior blood pressure lowering and cardiovascular protection compared to hydrochlorothiazide-based regimens.
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